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顺铂作为一种广谱抗肿瘤药物，它具有放射增强作用，尤其对于头颈部肿瘤中疗效明显提高，并且不增加急性反应，病人能耐受。本文采用前瞻性随机研究，对已确诊为鼻咽癌并有颈部淋巴结转移的７９例病人随机分为单纯放射组（Ⅰ组）和放射联合顺铂组（Ⅱ组）。放射治疗均采用同中心摆位，总量７０Ｇｙ／３５～３７次／７～８周。顺铂自放射开始后使用，１次／周，２０ｍｇ／ｍ２／次，共７～８次。分别以颈部转移性淋巴结缩小５０％和颈部皮肤干性脱皮来评价肿瘤组织放射效应及早期放射反应，结果获得治疗增益比提高１４％。急性反应主要是恶心、呕吐、口腔炎及干、湿性脱皮，但所有病人均能耐受而完成治疗。
Cisplatin as a broad-spectrum anticancer drug, which has a radiosensitizing effect, especially for the head and neck tumors significantly improved efficacy, and does not increase the acute response, the patient can tolerate. In this prospective and randomized study, 79 patients with nasopharyngeal carcinoma and cervical lymph node metastasis were randomly divided into radiotherapy group (Ⅰ group) and radiotherapy plus cisplatin group (Ⅱ group). Radiotherapy are used with the center position, the total 70Gy / 35 ~ 37 times / 7 ~ 8 weeks. Cisplatin used since the beginning of radiation, 1 / week, 20mg / m2 / time, a total of 7 to 8 times. The radiotherapy effect and early radiation response of tumor tissue were evaluated with 50% reduction of cervical metastatic lymph nodes and dry skin of neck. The results showed that the treatment gain ratio increased by 14%. Acute reactions are mainly nausea, vomiting, stomatitis and dry and wet peeling, but all patients are able to tolerate and complete the treatment.