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目的:探讨胺碘酮对食管癌、贲门癌开胸术后心律失常的预防作用。方法:167例食管癌、贲门癌的患者随机分为两组,预防组83例术前口服胺碘酮,开始为200 mg,3次/d,连服5 d后,改为200 mg/d至手术前,术后静脉使用胺碘酮,能进食后改200 mg/d口服。对照组84例,不予胺碘酮预防,观察两组患者术后各种并发症情况,房颤发生率及心室率的变化。结果:预防组房颤发生率、房颤时心室率均低于对照组,分别为6.0%vs 13.1%;(112±10.5)次/min vs(135±15.3)次/min,P均<0.05。结论:胺碘酮能安全有效降食管癌、贲门癌开胸术后房颤的发生率,减慢房颤发生时的心室率。
Objective: To investigate the preventive effect of amiodarone on cardiac arrhythmia after thoracotomy of esophageal and cardiac cancer. Methods: A total of 167 patients with esophageal and cardiac cancer were randomly divided into two groups. Preoperative oral amiodarone was given in 83 patients in the prophylaxis group, starting with 200 mg three times a day for 5 consecutive days and then changed to 200 mg daily Before surgery, intravenous amiodarone after surgery, can be changed after eating 200 mg / d orally. The control group of 84 patients without amiodarone to prevent postoperative complications, the incidence of atrial fibrillation and ventricular rate changes were observed. Results: The incidence of atrial fibrillation and atrial fibrillation in prevention group were lower than those in control group (6.0% vs 13.1%, 112 ± 10.5 / min vs 135 ± 15.3 / min, P <0.05 respectively) . Conclusion: Amiodarone can reduce the incidence of atrial fibrillation after thoracotomy in esophageal cancer and cardia cancer safely and effectively, and decrease the ventricular rate when atrial fibrillation occurs.