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耳和鼻部的免疫活性常被忽视,但可引起疾病。中耳重建被认为是应用组织移植最成功的例子。由于鼓膜下部形成坚韧的结缔组织块,听骨活动受阻,这种鼓膜硬化症可能起源于自身免疫。Ryan 采用损伤豚鼠鼓膜的方法来检验这一设想,豚鼠鼓膜事先用家兔抗体被动致敏。组织荧光试验证实在三天内兔抗豚鼠的γ-球蛋白参与鼓膜的炎症反应。如用眼镜蛇毒灭活补体,该反应就减弱。在6个月内鼓膜硬化发生在鼓膜损伤部位中层。
The immunological activity of the ears and nose is often overlooked but can cause illness. Middle ear reconstruction is considered the most successful example of the application of tissue transplantation. Due to the formation of a tough connective mass in the lower part of the tympanic membrane, the activity of the orbital bone is obstructed. Such eardrum sclerosis may originate from autoimmunity. Ryan uses guinea pig’s tympanic membrane to test this idea, guinea pig’s tympanic membrane was previously sensitized with rabbit antibodies. Tissue fluorescence assays confirmed that rabbit anti-guinea pig gamma-globulin was involved in inflammation of the tympanic membrane within three days. Such as cobra venom inactivation of complement, the reaction weakened. Within 6 months of tympanic sclerosis occurs in the tympanic membrane injury in the middle.