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慢性溃疡性结肠炎患者,特别是病变侵犯整个结肠和病程>10年的患者,以及儿童时即发病,初病时病情较重,成为慢性活动性病变者,易发生结肠癌。癌肿的症状易与结肠炎的相混淆,且癌肿可能是多中心性、平坦和浸润性的,不易被X线检查发现。Morson与Pang报道慢性溃疡性结肠炎癌变者的直肠活检标本中有癌前期病变——上皮间变,以后还发现这种间变可以不发生在直肠而散发于结肠。由于结肠镜检查的进展,已可从结肠各部作活检来查清有无间变。作者等对75例慢性溃疡性结肠炎患者,进行了结肠上皮间变与癌之间关
Chronic ulcerative colitis patients, especially the lesions invading the entire colon and duration of> 10 years of patients, and when the disease onset, severe illness at first onset, a chronic active disease, prone to colon cancer. The symptoms of cancer are easily confused with those of colitis, and the cancer may be multicentric, flat and invasive and not easily detected by X-rays. Morson and Pang report of chronic ulcerative colitis cancerous rectal biopsy specimens have precancerous lesions - epithelial metaplasia, and later found that this change can not occur in the rectum and distributed in the colon. Due to the progress of colonoscopy, biopsies have been available from various parts of the colon to ascertain whether there is any change. The authors of 75 cases of patients with chronic ulcerative colitis, between the colon epithelial metaplasia and cancer