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目的 了解血清可溶性肿瘤坏死因子受体 (STNFR) 1,2与胰岛素抵抗 (IR)的关系。方法 测定 43名男性和 41名绝经期前女性的STNFR1,2。以稳态模型 (HomaModel)公式评估IR。结果 肥胖男、女组STNFR1与非肥胖男、女组相近 ,而其STNFR2高于非肥胖男、女组 ,差异有显著性 (P <0 .0 5 )。所有男性STNFR1和STNFR2水平高于女性 (P <0 .0 1)。所有对象相关分析示STNFR2与臀腰比 (WHR)、空腹血糖、体重指数 (BMI)、HomaIR、空腹胰岛素正相关。STNFR1与上述指标无相关性。在男性中 ,STNFR2与瘦素正相关 (r =0 .34 ,P <0 .0 5 ) ,调整BMI、WHR影响后 ,STNFR2仍与瘦素正相关 (r=0 .30 ,P <0 .0 5 )。逐步回归分析示WHR和STNFR2对HomaIR的影响达 41.3%。结论 STNFR2与IR相关 ,在人类TNF系统对IR的影响可能主要通过TNFR2起作用。
Objective To investigate the relationship between serum soluble tumor necrosis factor receptor (STNFR) 1,2 and insulin resistance (IR). Methods Twenty-three male and 41 premenopausal women with STNFR1,2 were measured. IR was evaluated using the Homa Model formula. Results Compared with non-obese men and women, STNFR1 in obese men and women was significantly higher than that in non-obese men and women (P <0.05). All men had higher levels of STNFR1 and STNFR2 than women (P <0.01). Correlation analysis of all subjects showed that STNFR2 was positively correlated with WHR, fasting blood glucose, body mass index (BMI), HomaIR, fasting insulin. STNFR1 no correlation with the above indicators. In men, STNFR2 was positively correlated with leptin (r = 0.34, P <0.05). After adjusting for the influence of BMI and WHR, STNFR2 was still positively correlated with leptin (r = 0.30, P <0. 0 5). Stepwise regression analysis showed that the impact of WHR and STNFR2 on HomaIR was 41.3%. Conclusion STNFR2 is associated with IR. The effect of TNF in human TNF system may play an important role through TNFR2.