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目的研究单磷酸阿糖腺苷联合利巴韦林治疗小儿手足口病的疗效。方法将100例手足口病患儿,分为观察组和对照组,各50例,分别采用利巴韦林联合单磷酸阿糖腺苷和利巴韦林治疗。观察两组患儿疗效、住院时间、退热时间、皮疹消退时间及口腔溃疡愈合时间。结果观察组患儿治疗显效率高于对照组(P<0.05),平均住院时间、退热时间、皮疹消退时间及口腔溃疡愈合时间也短于对照组(P<0.05)。结论单磷酸阿糖腺苷联合利巴韦林治疗小儿手足口病,可快速改善症状,疗效显著。
Objective To study the efficacy of vidarabine monophosphate combined with ribavirin in the treatment of hand-foot-mouth disease in children. Methods 100 cases of hand-foot-mouth disease were divided into observation group and control group, 50 cases in each group. They were treated with ribavirin and ribavirin monophosphate respectively. The curative effect, hospitalization time, antipyretic time, rash subsidence time and oral ulcer healing time were observed in two groups. Results The effective rate of treatment in observation group was significantly higher than that in control group (P <0.05). The mean length of hospital stay, antipyretic time, rash subsidence time and healing time of oral ulcer were also shorter than those in control group (P <0.05). Conclusions The combination of vidarabine monophosphate and ribavirin for the treatment of hand-foot-mouth disease in children can rapidly improve the symptoms and has a significant therapeutic effect.