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新型重组人肿瘤坏死因子（ｒｈ－ＴＮＦ）系经基因重组、结构改建的肿瘤坏死因子。本研究旨在探讨ｒｈ－ＴＮＦ和化疗药５－氟尿嘧啶（５－ＦＵ）和丝裂霉素（Ｍｉｔｏｍｙｃｉｎ，ＭＭＣ）对恶性腹水的治疗效果，６４例恶性腹水分三组进行：Ｔ组（ＴＮＦ）２１例，ＦＭ组（５－ＦＵ，ＭＭＣ）１８例，ＴＦＭ组（ＴＮＦ，５－ＦＵ，ＭＭＣ）２５例。结果显示治疗恶性腹水的有效率分别为ＴＦＭ组９２．３％、Ｔ组８５．７％、ＦＭ组５０．０％。ＴＦＭ和Ｔ组较ＦＭ组疗效相差显著（Ｐ＜０．０１），ＴＦＭ和Ｔ组相差不显著（Ｐ＞０．０５），Ｔ组和ＴＦＭ组未见明显副作用。三组产生疗效的平均时间分别为ＴＦＭ组７．２ｄ、Ｔ组１１．５ｄ、ＦＭ组１８．２ｄ。表明ｒｈ－ＴＮＦ治疗恶性腹水具有疗效高，副作用小等优点。ｒｈ－ＴＮＦ和化疗药ＦＭ合用，可减少ＴＮＦ用量，缩短疗程，是治疗恶性腹水的理想方法。
New recombinant human tumor necrosis factor (rh-TNF) by gene recombination, structural remodeling of tumor necrosis factor. The purpose of this study was to investigate the effects of 5-fluorouracil (5-FU) and mitomycin (MMC) on the treatment of malignant ascites caused by rh-TNF and chemotherapy drugs. 64 cases of malignant ascites were divided into three groups: Twenty-one patients were treated with FMM (5-FU, MMC), 25 with TFM (5-FU, MMC) The results showed that the effective rate of malignant ascites were 92.3% in TFM group, 85.7% in T group and 50.0% in FM group. There was a significant difference (P <0.01) between the TFM and T groups and the difference between the TFM group and the T group (P> 0.05). No significant side effects were observed in the T and TFM groups. The average time to effect of the three groups were 7.2 days in TFM group, 11.5 days in T group and 18.2 days in FM group. That rh-TNF treatment of malignant ascites with high efficacy, side effects and other advantages. Combination of rh-TNF and chemotherapy drug FM can reduce the amount of TNF, shorten the course of treatment, is the ideal method of treatment of malignant ascites.