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[目的]通过测定血清IL-6、TNF-α、NO的变化水平情况,观察法舒地尔对急性心肌梗死(AMI)的治疗作用,探讨盐酸法舒地尔在心肌梗死炎症治疗方面的可能作用并评价其临床疗效。[方法]选择未能接受溶栓或急诊PCI治疗的急性心肌梗死患者共70例,随机分为法舒地尔组(治疗组)和对照组,两组均予硝酸甘油、阿司匹林、氯吡格雷及调脂等常规治疗,治疗组在对照组基础上加用盐酸法舒地尔(天津红日药业股份有限公司生产)30mg加入5葡萄糖注射液或生理盐水100ml静脉滴注,每日2次,连续治疗14d。[结果]在常规治疗基础上加用法舒地尔治疗急性心肌梗死对心功能的改善较对照组有效,血清炎症因子浓度水平与心肌梗死后心功能状态呈负相关。[结论]法舒地尔能有效保护急性心肌梗死后的存活心肌细胞,抑制心肌梗死急性期血清炎症因子峰值,从而减少炎症因子对心肌细胞的损害,并有效改善心功能,具有肯定的临床疗效。
[Objective] To observe the therapeutic effect of fasudil on acute myocardial infarction (AMI) by measuring the changes of serum IL-6, TNF-α and NO, and to explore the possible effect of Fasudil hydrochloride in the treatment of myocardial infarction Role and evaluation of its clinical efficacy. [Methods] A total of 70 acute myocardial infarction patients who failed to receive thrombolysis or emergency PCI were randomly divided into fasudil group (treatment group) and control group. Both groups were given nitroglycerin, aspirin, clopidogrel And lipid-lowering and other conventional treatment, the treatment group on the basis of the control group plus fasudil hydrochloride (Tianjin Hong Ri Pharmaceutical Co., Ltd.) 30mg added 5 glucose injection or saline 100ml intravenous infusion twice daily , Continuous treatment 14d. [Results] The improvement of cardiac function after fasudil treatment of AMI was more effective than the control group on the basis of routine treatment. The serum level of inflammatory cytokines was negatively correlated with the cardiac function after myocardial infarction. [Conclusion] fasudil can effectively protect the surviving cardiomyocytes after acute myocardial infarction, inhibit the peak of serum inflammatory cytokines in the acute phase of myocardial infarction, and thus reduce the damage of myocardial cells by inflammatory cytokines and effectively improve the cardiac function with definite clinical efficacy .