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目的:探讨超小超顺磁性氧化铁(USPIO)增强磁共振(MR)评估动脉粥样硬化(AS)斑块成分及易损性的价值。方法:将35只雄性新西兰大白兔随机分为2组,25只给予高脂饮食诱导AS,10只给予正常饮食作为对照组。所有扫描均在1.5TMR扫描仪上进行,采用Cardiac线圈。扫描序列包括:T1WISE,T2WIFSE,T2*WIGRE。所有动物于喂养10周开始扫描,完成平扫、USPIO增强24h扫描,1周后处死不同喂养阶段模型兔及同期对照组动物,每2周重复1次。USPIO使用剂量为0.05mmolFe/kg体重,MR所见与病理相对照。结果:除5只模型兔喂养中途死亡外,其余动物均完成全程扫描。所有模型兔大体标本均肉眼可见AS样改变。MR对10周模型兔病灶检出率40.0%,随病灶发展检出率明显提高。USPIO增强MR能更好识别斑块内各种成分,光镜及电镜检查示斑块内巨噬细胞可吞噬USPIO。结论:MR能动态监测AS病变并检出早期病灶;US-PIO增强MR对识别斑块成分具有独特价值,对判断斑块易损性具有较好价值。
Objective: To investigate the value of USPIO enhanced MR imaging in the evaluation of plaque composition and vulnerability of atherosclerosis (AS). Methods: Thirty-five male New Zealand white rabbits were randomly divided into 2 groups. 25 were given high-fat diet induced AS and 10 were given normal diet as control group. All scans were made on a 1.5 TMR scanner using a Cardiac coil. Scan sequences include: T1WISE, T2WIFSE, T2 * WIGRE. All animals began to scan at 10 weeks of feeding. The plain scan was performed. USPIO enhanced 24h scanning. One week later, rabbits in different feeding stages and control group were sacrificed every 2 weeks. USPIO dose of 0.05mmolFe / kg body weight, MR findings and pathology in contrast. Results: Except for 5 model rabbits, half of them died while feeding, and all other animals completed the whole scan. All models of rabbit gross specimens were visually observed AS-like changes. The detection rate of MR in 10-week rabbit model was 40.0%, which was significantly increased with the development of the lesion. USPIO enhanced MR can better identify various components within the plaque, light microscopy and electron microscopy showed plaque macrophages can swallow USPIO. CONCLUSION: MR can dynamically monitor AS lesions and detect early lesions. US-PIO-enhanced MR has unique value in identifying plaque components and has good value in judging plaque vulnerability.