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志贺菌感染是全球炎性腹泻和痢疾的重要原因。基于减毒志贺菌的第一代VirG的弱毒活疫苗株已成功地进行了Ⅰ、Ⅱ期临床试验,这是志贺菌疫苗开发的一个领先方法。senA、senB和msBb2中其他基因的缺失已应用到第二代VirG为基础的福氏
Shigella infection is an important cause of global inflammatory diarrhea and dysentery. The first generation VirG attenuated live vaccine strains based on attenuated Shigella have been successfully conducted Phase I and Phase II clinical trials and this is a leading method for the development of Shigella vaccines. The deletion of other genes in senA, senB and msBb2 has been applied to second-generation VirG-based Frees