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十四种消草磷结构类似物与经苯巴比妥预处理大鼠肝匀浆S9悬液一起温育,在有NADPH存在时,可不同程度地使P450失活.若温育10 min后P450丢失量用Y表示,化合物的疏水性和电性分别用P_(gc)和μ_(gc)表示,可建立如下相关性: logY=4.106logP_(gc)-0.575(logP_(gc))~2-5.822 (n=14,r=0.954,s=0.054);logY=3.678 logP_(gc)-0.520(logP_(gc))~2-0.037μ_(gc)-4.877 (n=14,r=0.965,S=0.049) 上述两方程表明,消草磷同类物体外使P450失活的能力与其疏水性呈良好的抛物线型相关,化合物的电性对此能力也有影响,但贡献较小.
Fourteen strains of the herbicidal phosphorus analogues were incubated with phenobarbital-pretreated rat liver homogenate S9 suspension. In the presence of NADPH, P450s were inactivated to varying degrees. If incubated for 10 min, The amount of P450 loss is denoted by Y. The hydrophobicity and electrical conductivity of the compound are denoted by P_(gc) and μ_(gc) respectively. The following correlation can be established: logY=4.106logP_(gc)−0.575(logP_(gc))~2 -5.822 (n=14, r=0.954, s=0.054); logY=3.678 logP_(gc)-0.520 (logP_(gc))~2-0.037μ_(gc)-4.877 (n=14, r=0.965, S = 0. 049) The above two equations indicate that the ability of P450 to inactivate P450 outside the same class of objects is a good parabolic type. The electrical properties of the compound also have an effect on this ability, but the contribution is small.