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目的:探讨足三里穴位注射白细胞介素-2(IL-2)联合干扰素-γ(IFN-γ)对晚期恶性肿瘤患者细胞免疫功能影响及临床意义。方法:经病理证实、Ⅲ~Ⅳ期的晚期恶性肿瘤患者70例随机分为七组,即IL-2穴注组、IL-2肌注组、IFN-γ穴注组、IFN-γ肌注组、IL-2+IFN-γ穴注组、IL-2+IFN-γ肌注组、穴注对照组。治疗前后检测外周静脉血中CD3+、CD4+、CD4+/CD8+比值,观察上述指标的变化。结果:治疗后各组比较,联合用药穴注组较联合用药肌注组和单药穴注组,以及单药穴注组、联合用药肌注组较单药肌注组CD4+、CD4+/CD8+明显升高(P<0.05),不良反应发生人次单药及联合用药穴注组低于相应肌注组(P<0.05),以上变化均有统计学意义。结论:IL-2联合IFN-γ足三里穴位注射较肌肉注射及单药应用能明显地增强晚期恶性肿瘤患者的细胞免疫功能,且副反应较小,方法简单。
Objective: To investigate the effect and clinical significance of interleukin-2 (IL-2) and interferon-γ (IFN-γ) injection on cellular immunity in patients with advanced malignant tumor. Methods: Seventy-five patients with advanced malignancies from stage Ⅲ to Ⅳ were randomly divided into seven groups: IL-2 point injection, IL-2 injection, IFN-γ injection, IFN-γ injection Group, IL-2 + IFN-γ point injection group, IL-2 + IFN-γ intramuscular injection group, point injection control group. The levels of CD3 +, CD4 +, CD4 + / CD8 + in peripheral venous blood before and after treatment were measured to observe the changes of these indexes. Results: Compared with the single injection group and single injection group, the combined injection group and the single injection group had significantly higher CD4 +, CD4 + / CD8 + ratio than the single injection group (P <0.05). Adverse reactions occurred in single drug group and combination therapy group (P <0.05), the above changes were statistically significant. Conclusion: Compared with intramuscular injection and monotherapy, IL-2 and IFN-γ can significantly enhance the cellular immune function in patients with advanced malignant tumor, and the side effects are less and the method is simple.