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本文用参附青注射液防治大鼠内毒素休克,证明静脉注射内毒素后立即滴注参附青注射液,血压保持原水平,滴注生理盐水组血压则持续下降至72.3±16.0 mmHg。对内毒素引起的低血压(80mmHg 以下)滴注参附青后上升至104.1±15.0mmHg,生理盐水组则无效(63.4±15.0mmHg)。内毒素与生理盐水分别从颈、股静脉滴注,可引起肠系膜微动脉收缩,参附青组则有显著拮抗作用。两组比较,滴注后90分钟 P<0.05,滴注后120分钟 P<0.01。提示参附青对早期内毒索性休克有较好的防治作用。
In this article, Shenfenqing injection was used to prevent and treat endotoxin shock in rats. It was proved that Shenfenqing injection was injected immediately after intravenous injection of endotoxin, blood pressure remained at the original level, and blood pressure in the saline group continued to drop to 72.3±16.0 mmHg. The endotoxin induced hypotension (below 80mmHg) was increased to 104.1±15.0mmHg after instillation of Shenfuqing, and the saline group was ineffective (63.4±15.0mmHg). Endotoxin and normal saline were injected from the neck and femoral veins, respectively, which could cause mesenteric arteriole contraction. The Shenfuqing group had significant antagonism. Compared with the two groups, P<0.05 at 90 minutes after instillation and P<0.01 at 120 minutes after instillation. It is suggested that Shenfuqing has better prevention and treatment of early internal toxic shock.