论文部分内容阅读
目的探讨急性胆红素脑病的磁共振成像(MRI)特征及其与预后的关系。方法回顾性分析2006年5月至2008年4月温州医学院附属第二医院暨育英儿童医院新生儿科11例急性胆红素脑病患儿的头颅MRI图像,以同期6例正常新生儿头颅MRI作对照。结果11例急性胆红素脑病中,8例双侧苍白球在T1WI呈对称性高信号,在T2WI呈正常的稍高信号,其余3例未见明显异常。对5例急性胆红素脑病患儿进行了随访研究,初次MRI异常的3例诊断为手足徐动型脑性瘫痪,其双侧苍白球T1WI上的高信号消失,T2WI上正常的稍高信号转为对称性高信号;初次MRI正常和异常各1例,临床随访神经发育均正常。结论双侧苍白球在T1WI呈对称性高信号是急性胆红素脑病相对特征性表现,由于病例数较少,MRI图像特征与临床预后的关系尚须进一步研究。
Objective To investigate the magnetic resonance imaging (MRI) features of acute bilirubin encephalopathy and its relationship with prognosis. Methods The MRI images of 11 children with acute bilirubin encephalopathy in the neonatology department of the Second Affiliated Hospital of Wenzhou Medical College and Yuying Children’s Hospital from May 2006 to April 2008 were retrospectively analyzed. Six normal neonatal skull MRIs Control. Results In 11 cases of acute bilirubin encephalopathy, 8 cases of bilateral globus pallidus showed symmetrical high signal on T1WI, normal high signal on T2WI, and the other 3 cases showed no obvious abnormality. Five children with acute bilirubin encephalopathy were followed up. The first three cases of MRI abnormalities were diagnosed as athetosis. The high signal on T1WI of both globus pallidus disappeared and the normal slightly higher signal on T2WI Turned to a high symmetry signal; first normal and abnormal MRI in 1 case, clinical follow-up of normal neurodevelopment. Conclusions The high symmetry of bilateral globus pallidus in T1WI is a relative characteristic manifestation of acute bilirubin encephalopathy. Due to the small number of cases, the relationship between MRI features and clinical prognosis needs to be further studied.