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目的探讨肺癌、慢性阻塞性肺病(COPD)患者血清抗核抗体(ANA)谱、类风湿因子(RF)的表现特点。方法采用免疫印迹法检测抗核抗体谱,免疫散射比浊法检测类风湿因子,对照分析86例肺癌病人、50例慢性阻塞性肺病病人及31例健康人血清抗核抗体谱、类风湿因子的表现特点。结果肺癌病人组ANA谱阳性率显著高于健康人组及COPD组,70岁以上老年肺癌患者组ANA谱阳性率显著高于50～70岁组,70岁以上老年肺癌患者ANA谱阳性率显著高于同年龄段健康人组及COPD组。结论肺癌与抗核抗体(ANA)谱有关。
Objective To investigate the characteristics of serum anti-nuclear antibody (ANA) and rheumatoid factor (RF) in patients with lung cancer and chronic obstructive pulmonary disease (COPD). Methods The antinuclear antibody spectrum was detected by immunoblotting and the rheumatoid factor by immunostaining turbidimetry. The serum anti-nuclear antibody spectrum of 86 patients with lung cancer, 50 patients with chronic obstructive pulmonary disease and 31 healthy controls were analyzed. Performance characteristics. Results The positive rate of ANA in patients with lung cancer was significantly higher than that in healthy people and COPD patients. The positive rate of ANA in patients with lung cancer over 70 years old was significantly higher than that in patients aged 50-70 years. The positive rate of ANA was significantly higher in patients over 70 years old with lung cancer In the same age group healthy people and COPD group. Conclusion Lung cancer is related to anti-nuclear antibody (ANA) spectrum.