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目的研究2型糖尿病患者糖化血红蛋白(HbA1c)与餐后2h C肽的关系,了解2型糖尿病患者胰岛素功能。方法用7600全自动生化分析仪及罗氏COBAS e411电化学发光分析仪测定158位健康人及149位2型糖尿病患者的HbA1c与餐后2h C肽,通过统计分析得出结果。结果 2型糖尿病患者的HbA1c与餐后2h C肽较对照组P<0.01,试验组与正常对照组的HbA1c与餐后2h C肽的测定结果组内男和女P>0.05。HbA1c与餐后2h C肽的相关系数r=0.714。结论 2型糖尿病患者的HbA1c与餐后2h C肽较对照组均有明显变化,差异有统计学意义。试验组与正常对照组的HbA1c与餐后2h C肽的测定结果组内男和女差别无统计学意义,HbA1c与餐后2h C肽之间呈正相关。
Objective To investigate the relationship between HbA1c and postprandial 2h C-peptide in type 2 diabetic patients and to understand the insulin function in type 2 diabetic patients. Methods HbA1c and postprandial 2h C peptide in 158 healthy subjects and 149 patients with type 2 diabetes were measured by a 7600 automatic biochemical analyzer and a Roche COBAS e411 electrochemiluminescence analyzer. The results were obtained by statistical analysis. Results HbA1c and postprandial 2h C peptide in patients with type 2 diabetes were significantly lower than those in the control group (P <0.01). The results of HbA1c and postprandial 2h C peptides in test group and control group were statistically significant (P> 0.05). The correlation coefficient between HbA1c and postprandial 2h C peptide was r = 0.714. Conclusions HbA1c in patients with type 2 diabetes mellitus and postprandial 2h C peptide have significant changes compared with the control group, the difference was statistically significant. There was no significant difference between male and female in determination of HbA1c and postprandial 2h C peptide in test group and normal control group, and there was a positive correlation between HbA1c and postprandial 2h C peptide.