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目的:评价介入化疗栓塞联合射频热疗对晚期胃癌的治疗效果。方法:回顾性分析70例晚期胃癌患者的临床资料,按治疗方法分为介入化疗栓塞联合射频热疗组(A组)与单纯介入化疗栓塞组(B组),观察比较临床症状、影像学、肿瘤标志的变化,以及毒副反应与生存期的差异。结果:术后两组临床症状、影像学和肿瘤标志均有显著改善,且A组优于B组(P<0.05),两组1、2、3年生存期分别为100.0%、90.1%、75.0%和100.0%、81.6%、44.7%,差异有统计学意义,P<0.05。两组均无严重并发症发生,差异无统计学意义,P>0.05。结论:介入栓塞化疗联合射频热疗能显著提高晚期胃癌患者的疗效,延长生存期,安全性高。
Objective: To evaluate the effect of interventional chemotherapy and radiofrequency ablation on advanced gastric cancer. Methods: The clinical data of 70 patients with advanced gastric cancer were retrospectively analyzed. According to the treatment methods, they were divided into interventional chemotherapy and embolization combined radiofrequency ablation group (group A) and simple interventional chemotherapy and embolization group (group B). Clinical symptoms, imaging, Changes in tumor markers, as well as differences in toxicity and survival. Results: The clinical symptoms, imaging and tumor markers in both groups were significantly improved after operation, and the A group was better than the B group (P <0.05). The 1, 2, 3 year survival rates were 100.0%, 90.1% 75.0% and 100.0%, 81.6% and 44.7%, respectively, the difference was statistically significant (P <0.05). No serious complications occurred in both groups, the difference was not statistically significant, P> 0.05. Conclusion: Interventional embolization chemotherapy combined with radiofrequency thermotherapy can significantly improve the efficacy of advanced gastric cancer patients, prolong survival and high safety.