,Oxidative damage and cell signaling transduction in patients of chronic myeloid leukemia

• 作 者: Deepti Pande Reena Negi Kanchan Karki Ranjana S.Khanna Hari D.Khanna
• 机 构: Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005,
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2015年6期
• 关键词: @@

Chronic myeloid leukemia (CML) was the first human malignancy shown to be consistently associated with a chromosomal abnormality,the Philadelphia chromosome.At the gene level,the Philadelphia chromosome is the result of breaks on chromosomes 9 and 22 with a reciprocal translocation of the distal genetic material.This translocation forms the new hybrid BCR-ABL oncogene,an abnormal 8.5-kb RNA that encodes a 210-kDa fusion protein,which,presumably through its increased tyrosine kinase activity,changes normal hematopoietic cells into CML cells [1].