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冠状病毒所致胃肠炎,在动物实验中已被广泛研究而肯定。从不同的动物中已分离到几株引起腹泻的病毒。在印度和英格兰首先用电镜检查到人肠道冠状病毒颗粒(CVLP),并提示与几种胃肠炎的流行有关。从不同地理区域的流行病学调查,人肠道CVLP似乎在热带地区比欧洲或北美洲更为常见。由于血清学试验尚未建立,CVLP只能靠电镜形态学特征来鉴定。CVLP为多形性,一般为80～300nm,但是圆形及>600nm直径的也常见到,它具有长度为15～45nm的典型刺突。
Coronavirus-induced gastroenteritis has been extensively studied and confirmed in animal experiments. Several strains of diarrhea virus have been isolated from different animals. Human gut coronavirus particles (CVLP) were first examined by electron microscopy in India and England, and were suggested to be linked to the prevalence of several gastroenteritis. From epidemiological surveys in different geographical regions, human intestinal CVLP appears to be more common in the tropics than in Europe or North America. Since serological testing has not been established, CVLP can only be identified by electron microscopic morphological features. CVLP is pleomorphic, typically 80-300 nm, but circular and> 600 nm diameter are also common, with typical spikes of 15-45 nm in length.