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IL-18是活化巨噬细胞产生的IFN-γ诱导因子。IL-18可增加脑实质中IFN-γ产生细胞数,增强活化小神经胶质细胞的功能〔1〕。体外实验证明肺巨噬细胞能选择性识别和杀伤被流感病毒感染的组织细胞,抑制流感病毒的增殖〔2〕。本研究利用IL-18基因缺陷鼠流感病毒感染模型,探讨IL-18在
IL-18 is an IFN- [gamma] -inducing factor produced by activated macrophages. IL-18 increases the number of IFN-γ-producing cells in the brain parenchyma and enhances the function of activated microglial cells [1]. In vitro experiments show that lung macrophages can selectively recognize and kill influenza virus infected tissue cells, inhibit influenza virus proliferation 〔2〕. In this study, the use of IL-18 gene-deficient murine influenza virus infection model to explore the IL-18 in