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一、引言早于1906年Bordet和Gay就发现牛血清中含有一种能使补体(通过抗体)致敏的红细胞(EAC)发生牢固凝集反应的成分,并发现这种成分对热稳定,56℃30分钟不被灭活。1909年Bordet和Streng把这种本质不同于凝集反应的现象称为团聚反应(Conglutinati-on)。把牛血清中固有的引起这种反应的物质命名为胶因素(Conglutinin:以下缩写为K)。五十年代前后,K已被一些学者(Blomfield和Coombs等)运用于血清学诊断(例如胶凝补体吸附试验——Conglutinating Complement Absorption Test),但是由于方法繁杂,特异性不同,没有引起广泛的兴趣。七十年代以来,由于免疫复合物的病理
I. INTRODUCTION As early as 1906, Bordet and Gay found that bovine serum contained a component that agglutinated aggresibly (by antibody) sensitized erythrocytes (EACs) and found that the composition was thermally stable at 56 ° C 30 minutes is not inactivated. In 1909, Bordet and Streng called this phenomenon different from the agglutination reaction called conglutination. The substance that causes this reaction inherent in bovine serum is named Conglutinin (hereinafter abbreviated as K). K has been used by some scholars (Blomfield and Coombs et al.) For serological diagnosis (such as the Condensing Complement Absorption Test) before and after the 1950s, but due to the complexity and specificity of the method, K did not attract widespread interest . Since the seventies, due to the immune complex pathology