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静脉注射茶硷用于治疗心肺疾患,剂量尚无明确规定。作者观察9名支气管哮喘发作后的患者,开始3小时均静脉滴注安慰剂为对照,然后静脉滴注茶硷。前6例患者在连续3小时内使茶硷的血浆浓度达到5、10、20毫克/升,后3例中2例使其血浆浓度维持在5毫克/升平段,另一例维持在10毫克/升。每小时测定一次肺功能。所有病例均见肺活量和一秒最大呼气量改善,与茶硷剂量有关。茶硷保持在恒定低血浆浓度平段可使肺功能不断改善。后3例肺功能也有不同程度进步,继续注入茶硷,并无进一步改善,因此,肺功能持续而稳定的变化显然与恒定的茶硷浓度有关。有3例患者于茶硷浓度最高平段时发生窦性心动
Intravenous theophylline for the treatment of heart and lung disease, the dose is not yet clearly defined. The authors looked at 9 patients who developed bronchial asthma and started placebo as a control for 3 hours of intravenous drip and then intravenous infusion of theophylline. The top 6 patients achieved a 5,10 and 20 mg / l plasma theophylline for 3 consecutive hours, 2 of the last 3 patients maintained their plasma concentration at 5 mg / l and the other remained at 10 mg / Rise. Pulmonary function was measured hourly. In all cases, the vital capacity and the maximum expiratory volume in one second were improved, which was related to theophylline dose. Theophylline maintained at a constant low level of plasma concentration of pulmonary function can continue to improve. After 3 cases of pulmonary function also have varying degrees of progress, continued infusion of theophylline, there is no further improvement, therefore, continuous and stable lung function changes obviously with the constant theophylline concentration. Three patients developed sinus rhythm at the highest level of theophylline