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目的确定放疗中化疗是否较放疗后化疗在治疗中晚期非小细胞肺癌中有效率、生存率等方面更好。方法将 1993年 2 1例中晚期非小细胞肺癌患者随机分成 2组。组 1为放疗中化疗 (n =11) ,组 2放疗后化疗 (n =10 ) ,化疗方案为CAP和EP交替使用 ,1次 / 3周。所有患者化疗次数均为 10次。肺部肿瘤放疗的剂量均为 6 0Gy ,30次 ,6周内完成。 结果完全缓解加部分缓解 :组 1为 90 .9% ,组 2为 40 .0 % ,两组有显著差异 (P <0 .0 5 )。生存率 :组 1中 1年生存率 45 .4% ,2年生存率 18.1% ,3年生存率 9.1% ,无 4年生存率。组 2中 1年生存率 40 % ,2年生存率 10 % ,无 3年生存率 ,两组无显著差异 (P >0 .0 5 )。结论放疗中化疗比放疗后化疗有较高的有效率 ,但未能证明放疗中化疗能改善生存率。
Objective To determine whether radiotherapy chemotherapy is better than radiotherapy chemotherapy in the treatment of advanced non-small cell lung cancer efficiency, survival and so on. Methods Twenty-one patients with advanced non-small cell lung cancer in 1993 were randomly divided into two groups. Group 1 was chemotherapy for radiotherapy (n = 11), and group 2 for chemotherapy after radiotherapy (n = 10). The chemotherapy regimen was alternated between CAP and EP once a week for 3 weeks. The number of chemotherapy in all patients were 10 times. The dose of lung cancer radiotherapy was 60 Gy, 30 times, and completed within 6 weeks. The results of complete remission and partial remission: group 1 90.9%, group 2 40.0%, the two groups were significantly different (P <0. Survival: Group 1 1-year survival rate 45.4%, 2-year survival rate 18.1%, 3-year survival rate 9.1%, no 4-year survival rate. In group 2, the 1-year survival rate was 40%, the 2-year survival rate was 10%, and there was no 3-year survival rate. There was no significant difference between the two groups (P> 0.05). Conclusion Radiotherapy chemotherapy is more effective than chemotherapy after radiotherapy, but failed to prove that radiotherapy chemotherapy can improve survival rate.