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目的 观察高频喷射通气结合小剂量氟碳 (3mL/kg)液体通气对吸入性损伤犬的血流动力学影响。方法 将16条犬经蒸气吸入造成吸入性损伤模型 ,并随机分为两组 ,即对照组和治疗组。两组动物致伤后均行高频喷射通气 ,但治疗组动物同时经气管导管将氟碳液体 (3mL/kg)缓慢注入肺内 ,在 90min内测定血流动力学指标。结果 治疗组动物的心率(HR)、平均动脉压 (PAP)、肺动脉嵌压 (PAWP)、心输出量 (CO)及每搏量 (SV)与伤后比较无统计意义 (P >0 0 5 ) ,但PAP在通气治疗 6 0、90min后与伤后比较略有升高 (P <0 0 5 ) ,HR、MAP、PAP、PAWP、CO及SV与对照组比较无统计意义 (P >0 0 5 )。结论 高频喷射通气合并小剂量氟碳 (3mL/kg)部分液体通气对吸入性损伤犬的血流动力学的主要参数无不利影响。
Objective To observe the hemodynamic effects of high-frequency jet ventilation combined with low-dose fluorocarbon (3 mL / kg) fluid ventilation on inhalation injury dogs. Methods 16 dogs were inhaled to cause inhalation injury model, and were randomly divided into two groups, control group and treatment group. Both groups of animals were subjected to high-frequency jet ventilation after injury. However, the animals in the treatment group were infused slowly with fluorocarbon liquid (3 mL / kg) through the endotracheal tube to determine the hemodynamics within 90 min. Results The heart rate (HR), mean arterial pressure (PAP), pulmonary arterial pressure (PAWP), cardiac output (CO) and stroke volume (SV) in the treatment group were not significantly different from those after injury ), But there was a slight increase in PAP at 60 and 90 minutes after ventilation (P <0 05). There was no significant difference in HR, MAP, PAP, PAWP, CO and SV between the two groups 0 5). Conclusion High-frequency jet ventilation combined with low-dose fluorocarbon (3 mL / kg) liquid ventilation has no adverse effect on the hemodynamic parameters of dogs with inhalation injury.