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目的:评价甲氨蝶呤与米非司酮联用对异位妊娠患者的临床疗效。方法:回顾性分析2013年6月—2015年6月妇产科收治确诊为异位妊娠的住院患者的临床资料140例,根据治疗方法的不同分为对照组(72例)和联用组(68例);对照组患者给予甲氨蝶呤治疗,联用组在对照组治疗的基础上加用米非司酮治疗,比较两组患者临床治疗的总有效率和临床症状消失时间。结果:联用组患者临床治疗后的总有效率为94.12%明显高于对照组为75.00%(P<0.05),腹痛消失时间、阴道流血停止出血时间、血β-HCG值恢复正常时间和盆腔包块消失时间均短于对照组(P<0.05)。结论:甲氨蝶呤与米非司酮联用治疗孕妇异位妊娠的临床疗优于单用甲氨蝶呤,且患者的临床症状消失快。
Objective: To evaluate the clinical efficacy of methotrexate and mifepristone in patients with ectopic pregnancy. Methods: The clinical data of 140 inpatients diagnosed as ectopic pregnancy in obstetrics and gynecology from June 2013 to June 2015 were retrospectively analyzed. According to the different treatment methods, they were divided into control group (72 cases) and combined group 68 cases). Patients in the control group were treated with methotrexate. The combination group was treated with mifepristone on the basis of the control group. The total effective rate of clinical treatment and the disappearance of clinical symptoms were compared between the two groups. Results: The total effective rate after the clinical treatment in the combined group was 94.12%, which was significantly higher than that in the control group (75.00%, P <0.05), the disappearance time of abdominal pain, bleeding stop bleeding time, the recovery time of blood β-HCG and pelvic The disappearance time of the mass was shorter than that of the control group (P <0.05). Conclusion: The combination of methotrexate and mifepristone for the treatment of ectopic pregnancy in pregnant women is better than methotrexate alone, and the clinical symptoms disappear rapidly.