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氯胺酮引起恶梦等不愉快的急性副反应,在小儿较成人少,因而成为小儿麻醉的常用药物。虽然以前报道氯胺酮无呼吸抑制作用,这点现已为动物实验所否定。近年来在成人的观察证实,氯胺酮减小其对二氧化碳的通气反应。但是,尽管已有几篇静脉注射氯胺酮后,在小儿引起呼吸骤停或低氧血症的报道,关于该药对小儿通气控制的影响仍无报告。本文即报道在小儿静脉注射后持续滴注氯胺酮对其通气控制的影响。作者在9例年龄6～10岁、体重20～48kg 的小儿,按2mg·kg~(-1)静脉注射。后40ug·kg~(-1)·min~(-1)连续输注氯胺酮。观察该药对二氧化碳通气反应的影响。作者发现,该药对静息呼吸频率(f),潮气量(V_T),呼气末二氧化碳分压(PETco_2)或每分钟通气量(VE)无影响。静脉注射氯胺酮5分
Ketamine causes unpleasant acute side effects such as nightmares and is less common in children than in adults, making it a commonly used drug for pediatric anesthesia. Although it has been previously reported that ketamine has no respiratory depression, this has now been denied in animal experiments. Observations in adults in recent years confirm that ketamine reduces its ventilatory response to carbon dioxide. However, although there have been several reports of respiratory arrest or hypoxemia in children after several intravenous ketamine doses, there is no report on the effect of this drug on pediatric ventilatory control. This article reports the effects of continuous drip infusion of ketamine on ventilatory control in infants after intravenous injection. The authors in 9 age 6 to 10 years old, weighing 20 ~ 48kg of children, according to 2mg · kg ~ (-1) intravenous injection. After 40ug · kg ~ (-1) · min ~ (-1) continuous infusion of ketamine. Observe the effect of the drug on carbon dioxide ventilation. The authors found no effect on the respiration rate (f), tidal volume (V_T), PETco_2, or VE. Intravenous ketamine 5 points