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铂类为主的化疗方案是治疗非小细胞肺癌的常用方案。目前常用的铂类抗肿瘤药物有顺铂和碳铂等[1] 。他们主要通过与ｐｙ -Ｇ -ｐｙ位点的鸟嘌呤相互作用 ,使细胞ＤＮＡ形成二齿加合物 ,产生细胞核毒性 ,发挥治疗肿瘤作用[2 ,3 ] 。但是此类药物可引起严重的肾小管损伤 ,降低肾
Platinum-based chemotherapy is a common regimen for the treatment of non-small cell lung cancer. The commonly used platinum anti-tumor drugs are cisplatin and carboplatin [1]. They interact with guanine at the py-G-py site to form bidentate adducts of DNA in cells that produce nuclear toxicity and play a role in tumor therapy [2,3]. However, such drugs can cause severe tubular damage, reduce the kidneys