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目的探讨平均血小板体积(MPV)与急性脑梗死预后的关系。方法回顾性分析了急性脑梗死患者120例,根据患者入院时平均血小板体积的参数大小分为4个组,即7.9～9.6fl组、9.7～10.9fl组、11.0～11.8fl组和11.9～17.8fl组。通过对患者在入院及出院时美国国立卫生研究院卒中量表(NIHSS)评分的比较,判断其神经功能缺损程度改善的情况。结果 4个组的患者出院时NIHSS评分比入院时明显下降,差异有统计学意义。多元线性回归分析显示NIH-SS下降值与患者住院天数、血小板计数(PLTC)及MPV呈正相关,其中PLTC和MPV对NIHSS下降值的影响较大。9.7～10.9fl组的NIHSS下降值与其他3组比较差异具有统计学意义,其余组间比较差异无统计学意义。结论 MPV参数的大小可能与急性脑梗死患者的预后有关。
Objective To investigate the relationship between mean platelet volume (MPV) and the prognosis of acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction were retrospectively analyzed. According to the parameters of mean platelet volume at admission, the patients were divided into 4 groups: 7.9 ~ 9.6fl group, 9.7 ~ 10.9fl group, 11.0 ~ 11.8fl group and 11.9 ~ 17.8 fl group. A comparison of the National Institutes of Health Stroke Scale (NIHSS) score on admission to and discharge from hospital to determine how well their neurological deficits improved. Results The NIHSS scores of patients in 4 groups were significantly lower than those at admission, the difference was statistically significant. Multivariate linear regression analysis showed that the NIH-SS decline was positively correlated with hospital stay, platelet count (PLTC) and MPV. PLTC and MPV had a significant impact on NIHSS decline. The NIHSS decrease in 9.7 ~ 10.9fl group was statistically significant compared with the other 3 groups, while there was no significant difference in other groups. Conclusions The size of MPV parameters may be related to the prognosis of patients with acute cerebral infarction.