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目前，新型冠状病毒(2019-nCoV)引起的新型冠状病毒肺炎(COVID-19)疫情呈大流行状态。2019-nCoV主要引起人类呼吸道感染并引起肺部组织结构和功能损害，已发现部分患者合并病毒性结膜炎，或以双眼病毒性结膜炎为首发症状，因此了解2019-nCoV的生物学行为及眼是否会被其感染非常重要。2019-nCoV主要通过与细胞表面的血管紧张素转化酶2(ACE2)结合侵入人类组织细胞，研究发现ACE2不仅表达于人肺脏、肾脏、心血管等器官，而且在人的结膜、角膜、房水及视网膜中也有表达。了解眼内ACE2的分布，有助于更加全面地认识COVID-19的感染机制和发病原因并且更好地了解眼科其他相关疾病的病理机制。ACE2是2019-nCoV侵染宿主的受体蛋白，同时也是肾素－血管紧张素系统(RAS)中的一个关键酶，眼部相对独立的RAS在维持眼的生理功能中发挥重要的调控作用，并且与许多眼科常见病有关。本文对ACE2在眼组织中的分布及其临床意义进行综述。“,”Coronavirus disease-19 (COVID-19) has reached pandemic status, and its pathogeny is the 2019 novel coronavirus (2019-nCoV).2019-nCoV mainly causes human respiratory infection and pulmonary inflammation; however, some COVID-19 patients are found to present viral conjunctivitis.Bilateral viral conjunctivitis is an initial symptom in some other cases.It is therefore, vital to understand whether the eye can be directly infected by the virus, as well as the consequences of the viral infection in the ocular tissue.2019-nCoV invades human cells primarily by binding to the angiotensin-converting enzyme 2 (ACE2) receptors.ACE2 expresses, not only in the lungs, kidneys, and cardiovascular system, but also in human conjunctiva, cornea, aqueous humor, and retina.Therefore, it is crucial to comprehensively expand the present understanding of the COVID-19 infection mechanism and pathogenesis by clarifying the distribution of ACE2 in the eye.ACE2 is not only the receptor of 2019-nCoV, but also a key enzyme in the renin-angiotensin system (RAS). RAS, which appears relatively independent in the eye, plays a modulating role and is associated with many common eye diseases.This article reviews the distribution and clinical significance of ACE2 in ocular tissues.