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目的探讨腹腔镜手术联合甲氨喋呤治疗异位妊娠的疗效。方法将2010年5月至2010年10月在广州市妇婴医院确诊为异位妊娠的56例患者随机分成两组。观察组:45例,采用腹腔镜手术联合甲氨喋呤(MTX),对照组:11例,单采用腹腔镜手术。比较两组患者治愈成功率、治疗前、后血β-HCG下降值及两种手术的住院时间。结果两组患者治愈成功率比较差异无统计学意义(P>0.05),观察组血β-HCG降至正常的时间明显快于对照组(P<0.05),两组术后的输卵管通水情况及两组住院天数比较差异无统计学意义(P>0.05)。结论采用腹腔镜手术联合甲氨喋呤治疗异位妊娠能更快、更有效地抑制滋养细胞增长,提高疗效,缩短治疗时间,减少治疗费用。
Objective To investigate the efficacy of laparoscopic surgery combined with methotrexate in the treatment of ectopic pregnancy. Methods Fifty-six patients with ectopic pregnancy diagnosed in Guangzhou Maternal and Child Hospital from May 2010 to October 2010 were randomly divided into two groups. Observation group: 45 cases, using laparoscopic surgery combined with methotrexate (MTX), control group: 11 cases, single laparoscopic surgery. The successful rate of cure, the decline of β-HCG in blood before and after treatment and the length of hospital stay of the two kinds of surgery were compared between the two groups. Results There was no significant difference in the success rate of cure between the two groups (P> 0.05). The time to normal blood β-HCG in the observation group was significantly faster than that in the control group (P <0.05) There was no significant difference between the two groups in hospitalization days (P> 0.05). Conclusion The combination of laparoscopic surgery and methotrexate treatment of ectopic pregnancy faster and more effectively inhibit the growth of trophoblastic cells to improve efficacy, shorten the treatment time and reduce the cost of treatment.