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金属基药物被广泛应用于癌症化疗且具有良好前景。在过去的几十年中,希夫碱及衍生物因其广泛的生物潜能而被广泛知晓。在现在的研究中,Hajrezaie M等评估了铜Ⅱ复合物对结肠癌细胞的抗恶性细胞增殖效果,结果提示,在接受了2.87μg/m L铜Ⅱ复合物治疗72 h后,对HT-29结肠癌细胞具有抗恶性细胞增殖的作用。接受过铜Ⅱ复合物治疗的HT-29细胞经历了细胞凋亡。对染色细胞进行荧光强度检查后发现,6.25μg/m L的铜Ⅱ复合物会显著提高活性氧产物,但会伴随线粒
Metal-based drugs are widely used in cancer chemotherapy and have good prospects. Schiff bases and derivatives have been widely known for their extensive biological potential over the past decades. In the present study, Hajrezaie M et al evaluated the anti-malignant cell proliferation effect of copper II complex on colon cancer cells and found that after 72 h of treatment with 2.87 μg / m L Cu Ⅱ complex, HT-29 Colon cancer cells have anti-malignant cell proliferation. HT-29 cells treated with copper II complex underwent apoptosis. Fluorescence intensity examination of stained cells revealed that 6.25 μg / mL of copper II complex significantly increased ROS, but was associated with mitochondria