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目的:对不同剂量泼尼松联合甲氨蝶呤治疗类风湿关节炎的临床疗效进行的评价。方法:选择92例类风湿性关节炎患者,随机分为小剂量组和中剂量组,各46例,小剂量组采用小剂量泼尼松联合甲氨蝶呤治疗,中剂量组采用中等剂量泼尼龙联合甲氨蝶呤治疗,观察两组患者临床指标的变化。结果:两组患者在接受治疗十二周后关节功能评分、VAS评分、红细胞沉降率、晨僵时间均明显降低;两组患者在治疗后上述指标差异无统计学意义。小剂量组发生不良反应11例,中剂量组发生不良反应26例,差异具有统计学意义。结论:使用小剂量泼尼松联合甲氨蝶呤治疗类风湿性关节炎疗效好,且不良反应的发生率低,尤其是能减轻胃肠道不良反应,值得临床推广。
Objective: To evaluate the clinical efficacy of different doses of prednisone combined with methotrexate in the treatment of rheumatoid arthritis. Methods: Ninety-two patients with rheumatoid arthritis were randomly divided into low-dose group and middle-dose group, with 46 cases in each group. The low-dose prednisone combined with methotrexate was used. The middle-dose group Nylon combined methotrexate treatment, changes in clinical indicators of two groups were observed. Results: The scores of joint function, VAS score, erythrocyte sedimentation rate and morning stiffness were significantly decreased in both groups after 12 weeks of treatment. There was no significant difference in the above indexes between the two groups after treatment. There were 11 cases of adverse reactions in low dose group and 26 cases of adverse reaction in middle dose group, the difference was statistically significant. Conclusions: The treatment of rheumatoid arthritis with low dose prednisone combined with methotrexate is effective, and the incidence of adverse reactions is low, especially to reduce gastrointestinal adverse reactions, it is worth clinical promotion.