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1938年 Banting 等首先描述了经过胰岛素(INS)休克治疗的病人对 INS 产生抗药性,并认为在这类人群中存在 INS 抗体.本文就糖尿病患者对外源(?)NS 产生的免疫反应及其对糖尿病的影响作一综述.一、影响 INS 免疫原性的因素继上述 Banting 等报道后,1987年 Oakley等在一些用 INS 治疗的糖尿病人中发现由 INS 抗体导致的 INS 抗性.对 INS 的过敏反应也有报道.最初认为过敏反应是由天然胰腺抽提物中的杂质所引起,而不是 INS 本身.糖尿病人对 INS 作为免疫原的反应性因人而异,差别很大,其循环抗体的量在不同病人也有很大差异.人和猪的 INS 可能不具免疫原性,除非在生产或储存过程中发生物理变化使其成为带有“外来”抗原决定簇的聚合物.牛 INS 比猪和人的 INS 有更强的免疫原性,但经过纯化可使其抗原性显著降低.在用猪、人的高纯
In 1938, Banting et al. First described the resistance of INS patients to insulin shock therapy and the existence of INS antibodies in these populations. In this paper, the immune responses to exogenous NS in diabetic patients and their effects on Diabetes mellitus.Materials and Methods1. Factors Influencing the Immunogenicity of INS Following the above report by Banting et al., Oakley et al found INS resistance caused by INS antibody in some diabetic patients treated with INS in 1987. Allergy to INS Reactions have also been reported.It was initially thought that anaphylaxis is caused by impurities in natural pancreatic extracts rather than INS itself.Diabetics vary widely in the reactivity of INS as an immunogen with varying amounts of circulating antibodies There are also large differences between patients and humans. INS in humans and pigs may not be immunogenic unless they undergo physical changes during production or storage making them polymers with “foreign” antigenic determinants. Of INS is more immunogenic, but after purification can significantly reduce its antigenicity in pigs, human high purity