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据近来一些地区反映,有极少数疟疾病人采用伯氨喹啉五日疗法之后发生“溶血”反应。伯氮喹啉可以对红细胞缺乏6—磷酸葡萄糖脱氢酶(G—6—PD)的个体导致急性血管内溶血的严重副反应,已是引起国内外广泛注意的事实。我省仅于一九六五年在局部地区进行过人群 G—6—PD 缺乏的初步调查(张广兴,1965,未发表资料);但全省这种体质上的生化缺陷分布情况和发生率均不清楚。因此建议有条件的地区可开展此项普查,开始可先在伯喹溶血者及其家族中进行,摸索经验,逐步扩大调查范围,以便澄清 G—6—PD 缺乏分布情况,采取预防措施,最大限度降低伯氨喹啉的副反应发生率。
Recently, some areas have reported that there are very few malaria patients who have undergone “hemolysis” after using primaquine for five days. The serious side effects of primary aztreotide on acute intravascular hemolysis in individuals with erythrocytes lacking 6-phosphoglucose dehydrogenase (G-6-PD) have been the subject of widespread attention at home and abroad. The province conducted a preliminary survey of the G-6-PD lack of population in some areas only in 1965 (Zhang Guangxing, 1965, unpublished data); however, the distribution and incidence of such biochemical defects in the province Not clear. Therefore, it is suggested that the census should be carried out in areas where conditions permit. The trial may first be carried out in Primoly hemolysis patients and their families to explore the experience and gradually expand the scope of the investigation so as to clarify the lack of distribution of G-6-PD and take precautionary measures Limits the incidence of primaquine side effects.