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在热处理凝血因子浓缩物应用之前,几乎所有首次输注因子Ⅷ治疗的血友病患者均染上非甲非乙型肝炎(NANBH).本文着重探讨血友病患者血清丙型肝炎病毒抗体(抗-HCV)携带状况及凝血因子浓缩物输注与丙型肝炎发生的关系.采用放免法对154例血友病患者进行血清抗-HCV检测,结果129例接受因子Ⅷ或Ⅸ患者76例(59%)抗-HCV阳性.55例每年需要10000单位凝血因子浓缩物的病人42例(76%)抗-HCV阳性,74例
Prior to the heat treatment of clotting factor concentrates, almost all hemophiliacs treated with factor VIII were infected with non-A, non-B hepatitis (NANBH) before the application of the clotting factor concentrate.This article focused on the detection of serum hepatitis C virus antibodies -HCV) and the relationship between the coagulation factor concentrate infusion and the occurrence of hepatitis C. Serum anti-HCV was detected in 154 patients with hemophilia by radioimmunoassay, and the results showed that among the 129 patients receiving factor Ⅷ or Ⅸ, 76 %) Were positive for anti-HCV. Forty-five (76%) patients who required 10000 units of clotting factor concentrate per year were anti-HCV positive and 74