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目的探讨神经外科手术患者在手术过程中发生医院感染的原因及护理干预方法，从而达到降低手术室相关医院感染的发生率。方法对我院神经外科2009年2月~2012年12月，12例发生医院感染的住院患者病例进行回顾性分析。结果手术类型、手术环境、手术时间、是否接台手术、术前抗生素应用、手术区人员活动，均对手术的感染有影响，（P<0.05）。结论在神经外科手术中必须采取一系列的护理干预措施，以降低手术中感染的发生率，提高手术成功率有利于患者的预后。“,”Objective To investigate the cause of neurosurgery operation in nosocomial infection occurs during operation and the nursing intervention methods, providingthe reference to reduce the incidence of nosocomial infection in operating theatre. Methods The nosocomial infection of 12 neurosurgical patients were investigated and retrospectively analyzed in our hospital from 2009 Feb to 2012 Dec.Results Types of surgery, surgical environment, time in surgery, consecutive emergencyoperation andpreventive use of antibioticswere closely related to nosocomial infection (P<0.05).Conclusion A series of nursing intervention measures was taken to reduce the incidence of infection intheoperation,thesemeasures may help to improve the prognosis of the patients .