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目的探讨急性上消化道出血(UGIH)患者外周血炎症指标变化及临床意义。方法选取2014年1月至2015年4月收治的72例UGIH患者为研究对象(UGIH组),收集其外周血样标本,检测C反应蛋白(CRP)、白细胞介素(IL)-6和IL-10水平,同时选取年龄、性别匹配的消化性溃疡患者68例(溃疡组)和健康体检者50例(健康组)为对照。结果 UGIH组的CRP、IL-6和IL-10水平为(8.94±2.53)mg/L、(7.24±2.67)pg/L和(1.43±0.89)pg/L,其CRP水平与IL-6呈正相关(r=0.527),IL-10水平与CRP、IL-6与呈负相关(r=-0.367、-0.442)。UGIH组CRP、IL-6水平高于对照组和溃疡组,而IL-10水平低于对照组和溃疡组(P<0.05),且治疗后的以上指标获改善(P<0.05)。结论 UGIH患者外周血炎症指标出现异常,可用于辅助UGIH诊断并反映疗效。
Objective To investigate the changes and clinical significance of peripheral blood inflammation in patients with acute upper gastrointestinal hemorrhage (UGIH). Methods Seventy-two patients with UGIH admitted from January 2014 to April 2015 were enrolled in the UGIH group. Peripheral blood samples were collected for the detection of C-reactive protein (CRP), interleukin (IL) -6 and IL- 10 levels. At the same time, 68 cases of peptic ulcer (ulcer group) and 50 healthy people (healthy group) were selected as controls. Results The levels of CRP, IL-6 and IL-10 in UGIH group were (8.94 ± 2.53) mg / L, (7.24 ± 2.67) pg / L and (1.43 ± 0.89) pg / L, (R = 0.527). The level of IL-10 was negatively correlated with CRP and IL-6 (r = -0.367, -0.442). The levels of CRP and IL-6 in UGIH group were higher than those in control group and ulcer group, while the levels of IL-10 in ulcer group were lower than those in control group and ulcer group (P <0.05). The above indexes were improved after treatment (P <0.05). Conclusion There are abnormal peripheral blood inflammation in UGIH patients, which can be used to assist the diagnosis of UGIH and reflect the curative effect.