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本文评价英国新生儿筛查检出的先天性甲低诊断时甲状腺素(T_4)浓度和临床特征之间的关系。对象和方法 1990年初调查了449例(男139例;女310例)于1982年～1984年出生经新生儿筛查诊断的先天性甲低患儿。并与1988年出生的36727例正常人群比较。372例测定总 T_4:75例测游离T_4(FT_4);2例测 T_3。55例 FT_4按公式 LogT_4=
This article evaluates the relationship between the thyroxine (T_4) concentration and clinical features in neonates with hypothyroidism detected in neonatal screening in the United Kingdom. Subjects and Methods In early 1990, 449 cases (139 males and 310 females) were enrolled in this study. Children with congenital hypothyroidism diagnosed by neonatal screening from 1982 to 1984 were enrolled. Compared with 36,727 normal subjects born in 1988. 372 cases of total T_4: 75 cases measured free T_4 (FT_4); 2 cases of T_3.55 cases of FT_4 according to the formula LogT_4 =