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中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)中的渗透性评价,需多成分作为整体来开展研究,即使在研究具体某一成分时,也应将其放在多成分环境中审视。该实验以此为原则,将葛根芩连汤中的高含量成分作为多成分环境影响因素,考察葛根素的肠渗透性,运用在体肠单向灌流模型,对葛根素肠渗透性的相关参数进行测定,评价其他高含量成分对其肠渗透性的影响。实验结果表明不同比例的黄芩苷、甘草酸和小檗碱对葛根素的肠渗透性均有一定的影响,甘草酸能显著抑制葛根素的肠吸收,高浓度小檗碱会促进葛根素的吸收。该研究结果表明中药生物药剂学分类系统的渗透性评价充分考虑多成分环境中其他成分的影响是重要的研究思想。
The evaluation of permeability in the biopharmaceutics classification system of Chinese materia medica (CMMBCS) requires multiple components to be studied as a whole. Even when studying a particular component, it should be placed in a multi-component environment In review. Based on this principle, the high content of Gegen Qinlian Decoction as a multi-component environmental factors, the study of puerarin intestinal permeability, the use of in vivo intestine intestinal perfusion model of puerarin intestinal permeability related parameters The determination of other high content of ingredients on the intestinal permeability. The experimental results show that baicalin, glycyrrhizin and berberine have different effects on the intestinal permeability of puerarin. Glycyrrhizic acid can significantly inhibit the intestinal absorption of puerarin, and the high concentration of berberine can promote the absorption of puerarin . The results of this study indicate that it is an important research idea to fully consider the influence of other components in the multi-component environment on the evaluation of the permeability of the Chinese medicine biopharmaceutical classification system.