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目的 研究１，６二磷酸果糖（ＦＤＰ）对体外循环（ＣＰＢ）手术病人围术期红细胞免疫粘附功能（ＲＣＩＡ）的影响。方法 ２４ 例心内直视手术患者随机分为２ 组，生理盐水（ＮＳ）组和ＦＤＰ组各１２例，两组分别于麻醉前、ＣＰＢ前、停机后５ 分钟、术后２４ 小时、术后７２ 小时抽取静脉血检测红细胞Ｃ３ ｂ 受体花环形成率（ＲＢＣ·Ｃ３ｂＲ）及红细胞免疫复合物花环形成率（ＲＢＣ·ＩＣＲ）。结果 停机后及术后２４ 小时，ＮＳ组患者ＲＢＣ·Ｃ３ｂＲ 及ＲＢＣ·ＩＣＲ 均显著下降，ＲＢＣ·Ｃ３ｂＲ 下降率分别为２７６６％ ，３２１０％ （Ｐ＜ ００１）；ＲＢＣ·ＩＣＲ下降率分别为２３２８％ ，３２１６％ （Ｐ＜ ００１）；而ＦＤＰ组停机后及术后２４ 小时，ＲＢＣ·Ｃ３ｂＲ分别降低１６１５％ ，２０３９％ ，与术前相比降低明显（Ｐ＜ ００１）；但与ＮＳ组相比，其降低程度则有所减少（Ｐ＜ ００５）；ＲＢＣ·ＩＣＲ降低分别为１８２８％ ，２２８１％ ，与ＮＳ组相比无统计学差异；术后ＲＣＩＡ 功能恢复ＦＤＰ组较ＮＳ组亦有所提高。结论 ＦＤＰ（２００ｍ ｇ／ｋｇ）于ＣＰＢ术前应用对ＲＣＩＡ有显著性保护作用
Objective To study the effect of fructose-1,6-diphosphate (FDP) on perioperative erythrocyte immune-adhesive function (RCIA) in patients undergoing cardiopulmonary bypass (CPB). Methods Twenty - four patients undergoing open heart surgery were randomly divided into 2 groups: NS (n = 12) and FDP (n = 12). The two groups were given before anesthesia, before CPB, after 5 minutes, after 24 hours, Venous blood samples were taken at 72 hours to detect the formation rate of erythrocyte C3 b rosette (RBC · C3bR) and erythrocyte immune complex rosette formation rate (RBC · ICR). Results After stopping and at 24 hours after operation, the RBC · C3bR and RBC · ICR of patients in NS group were significantly decreased, the decreasing rates of RBC · C3bR were 2766% and 3210% respectively (P0.01); RBC · ICR (P <001). The rates of RBC · C3bR decreased by 1615% and 2039% respectively in the FDP group after stopping and at 24 hours after operation, (P <001), but decreased compared with NS group (P <005). The reduction of RBC · ICR was 1828% and 2281% respectively, Compared with NS group, there was no significant difference; RCIA function restored after FDP group than NS group also increased. Conclusion The application of FDP (200 m g / kg) before CPB has a significant protective effect on RCIA