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目的探讨转化生长因子-β1(TGF-β1)在卵巢上皮性癌的表达。方法应用免疫组化SP法检测80例卵巢上皮性癌的表达。结果 80例卵巢上皮性癌中年龄≤60岁阳性表达率为42.1%(26/62),>60岁的阳性表达率为43.8%(10/22),两者比较差异无统计学意义(P=0.82);在浆液性癌的阳性表达率明显高于黏液性癌和子宫内膜样癌(χ2=8.16,P=0.02);在不同FIGO分期的表达差异有统计学意义(χ2=10.30,P=0.05)。结论 TGF-β1的表达与卵巢上皮性癌的侵袭和转移密切相关,可以作为评价卵巢上皮性癌的重要生物学指标。
Objective To investigate the expression of transforming growth factor-β1 (TGF-β1) in epithelial ovarian cancer. Methods Immunohistochemical SP method was used to detect the expression of 80 cases of epithelial ovarian cancer. Results The positive expression rate of 80 cases of epithelial ovarian cancer ≤60 years old was 42.1% (26/62), and the positive expression rate of> 60 years old was 43.8% (10/22), the difference was not statistically significant (P = 0.82). The positive expression rate in serous carcinoma was significantly higher than that in mucinous carcinoma and endometrioid carcinoma (χ2 = 8.16, P = 0.02). There was significant difference in different FIGO stages (χ2 = 10.30, P = 0.05). Conclusion The expression of TGF-β1 is closely related to the invasion and metastasis of epithelial ovarian cancer, which may be used as an important biological indicator for the evaluation of epithelial ovarian cancer.