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目的:评价咪唑安定与吗啡联合使用在新生儿机械通气治疗中的临床疗效。方法:选择在新生儿重症监护病房(NICU)机械通气治疗的患儿,共45例,随机分为观察组(咪唑安定+吗啡)20例、对照组(咪唑安定)25例。观察两组治疗后2 h的PO2、PCO2、PIP、PEEP、呼吸、心率、平均动脉压之间的差异,并比较两组机械通气时间及咪唑安定的用量。结果:两组患儿都可以达到满意的镇静效果,观察组咪唑安定的用量、机械通气时间、PO2、PCO2与对照组比较有统计学差异,两组间的RR,HR,MAP比较,均无统计学差异。结论:咪唑安定与吗啡联合使用,可以达到良好的镇静效果,有利于改善氧合状态,减少咪唑安定的用量,缩短呼吸机使用时间。
Objective: To evaluate the clinical efficacy of midazolam in combination with morphine in neonatal mechanical ventilation. Methods: A total of 45 children with mechanical ventilation in neonatal intensive care unit (NICU) were randomly divided into observation group (midazolam + morphine) in 20 cases and control group (midazolam) in 25 cases. The differences of PO2, PCO2, PIP, PEEP, respiration, heart rate and mean arterial pressure at 2 h after treatment were observed. The duration of mechanical ventilation and the dosage of midazolam were compared between the two groups. Results: The two groups of children can achieve satisfactory sedation, the observation group the amount of midazolam, mechanical ventilation time, PO2, PCO2 compared with the control group were statistically significant, RR, HR, MAP between the two groups were no Statistical differences. Conclusion: The combination of midazolam and morphine can achieve good sedation effect, improve oxygenation status, reduce the dosage of midazolam and shorten the time of ventilator use.