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目的: 明确绝经后乳腺癌的临床特征及与绝经前乳腺癌的异同性。方法:对绝经前、后乳腺癌患者的首发症状、病程、临床分期及受体状态等指标进行回顾性对照分析。组间比较采用x~2检验,P<0.05认为差异有统计学意义。结果:浸润性导管癌是绝经前后两组患者的主要病理类型,T_4和N_0患者在绝经后组较绝经前组明显增高(x~2=10.62,P<0.01;x~2=5.72,P<0.05),N_1患者则明显低于绝经前组(x~2=6.09,P<0.05);在相同肿瘤大小情况下,绝经后组的转移率均低于绝经前组;绝经后组PR阳性者较绝经前组明显减少(x~2=13.9,P<0.01),ER和HER-2表达则无差异;绝经前、后两组分子亚型与腋窝淋巴结转移无关。结论:本研究结果初步显示绝经后乳腺癌的临床特征与绝经前患者总体上存在相似性,但又具有其独特性,对绝经后乳腺癌的生物学特性及其对疗效和预后的影响需进一步探讨。
Objective: To clarify the clinical characteristics of postmenopausal breast cancer and its homology with premenopausal breast cancer. Methods: The pre-menopausal and post-menopausal women’s first symptom, course of disease, clinical stage and receptor status were retrospectively analyzed. Comparison between groups using x ~ 2 test, P <0.05 that the difference was statistically significant. Results: The invasive ductal carcinoma was the main pathological type in both groups before and after menopause. T_4 and N_0 patients in postmenopausal group were significantly higher than premenopausal group (x ~ 2 = 10.62, P <0.01; x ~ 2 = 5.72, P < 0.05), while the N_1 patients were significantly lower than the premenopausal group (x ~ 2 = 6.09, P <0.05); in the same tumor size, the metastasis rate of postmenopausal group was lower than that of premenopausal group; Which was significantly lower than that of the premenopausal group (x ~ 2 = 13.9, P <0.01). There was no difference in the expression of ER and HER-2 between the premenopausal and postmenopausal women. The molecular subtypes had no correlation with the axillary lymph node metastasis. CONCLUSIONS: The results of this study initially show that the clinical characteristics of postmenopausal women with breast cancer generally have similarities with those of premenopausal women, but they also have their uniqueness. Therefore, the biological characteristics of postmenopausal breast cancer and their effects on prognosis and outcome need to be further Discussion.