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目的研究乳腺癌患者血清中微量元素含量与乳腺癌风险的关系。方法应用三电极直流等离子体原子发射光电直读光谱仪(DCP-AES)测定88例乳腺癌患者和50例正常对照者血清中Zn、Mn、Al、Cd、Fe、Mg、Ca、Pb、Cu、Ni、Co、Ti、Li和Cr含量,比较两组间血清微量元素含量的差别。结果与正常对照者相比,乳腺癌患者血清中Cd、Mg、Cu、Co、Li和Cr含量明显升高,Mn、Al、Ti和Fe含量则明显降低,差异均有统计学意义(P均<0.05),而Zn、Ca、Pb和Ni含量差异均无统计学意义(P均>0.05)。结论血清微量元素含量可能影响乳腺癌风险,测定血清中微量元素含量可能对乳腺癌有诊断价值。
Objective To study the relationship between serum levels of trace elements and the risk of breast cancer in breast cancer patients. Methods The serum levels of Zn, Mn, Al, Cd, Fe, Mg, Ca, Pb, Cu and Cu in 88 cases of breast cancer patients and 50 normal controls were measured by DC- Ni, Co, Ti, Li and Cr contents were compared between the two groups to compare the content of serum trace elements. Results The serum levels of Cd, Mg, Cu, Co, Li and Cr in breast cancer patients were significantly higher than those in normal controls, while the contents of Mn, Al, Ti and Fe were significantly decreased (P <0.05), while the contents of Zn, Ca, Pb and Ni showed no significant difference (all P> 0.05). Conclusion Serum trace element levels may affect the risk of breast cancer. Determination of trace elements in serum may have diagnostic value for breast cancer.