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目的探讨胃肠道间质瘤的病理和免疫组化的特点及之间的关系。方法免疫组化标记CD117、CD34、SMA、S-100蛋白4种抗体于胃肠道间叶源性肿瘤,确诊24例间质瘤,对其进行临床病理组织学和免疫组化分析。结果免疫组化显示24例GIST中CD117阳性表达率为87.5%,CD34的阳性表达率为79.2%;SMA的阳性表达率为41.7%;S-100的阳性表达率为8.3%。结论CD117、CD34对胃肠间质瘤特异性表达,具有临床应用的价值。GIST多发于中老年,肿瘤细胞形态多样,结构多样;免疫组化CD117和CD34阳性表达是确诊间质瘤最有诊断价值的依据,但间质瘤良、恶性诊断上仍需结合肿瘤的大体、组织学形态及生物学行为等综合考虑。
Objective To investigate the pathological and immunohistochemical characteristics of gastrointestinal stromal tumors and their relationship. Methods Four kinds of antibodies, CD117, CD34, SMA and S-100, were labeled by immunohistochemistry in 24 patients with gastrointestinal stromal tumors. Twenty-four patients were diagnosed as GISTs. The histopathological and immunohistochemical analysis was performed. Results Immunohistochemistry showed that the positive expression rate of CD117 in 24 cases of GIST was 87.5%, the positive expression rate of CD34 was 79.2%, the positive expression rate of SMA was 41.7% and the positive expression rate of S-100 was 8.3%. Conclusion The expression of CD117 and CD34 on gastrointestinal stromal tumors is of clinical value. GIST is more common in middle-aged and elderly patients. The tumor cells are diverse and diverse in structure. The positive expression of CD117 and CD34 on immunohistochemistry is the basis for the diagnosis of stromal tumors. However, Histological morphology and biological behavior comprehensive consideration.