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目的：研究盐酸洛美沙星的急性毒性。方法：参照药理实验方法学的方法测定其ＬＤ５０，１００只昆明小鼠随机分为５组尾静脉注射给药，观测４８小时内每组小鼠死亡数。结果：盐酸洛美沙星雌性小鼠组，ＬＤ５０＝２５５．３ｍｇ／ｋｇ；雄性小鼠ＬＤ５０＝２５１．２ｍｇ／ｋｇ，与盐酸洛美沙星葡萄糖注射液相比（ＬＤ５０＝２６１．２ｍｇ／ｋｇ）无明显差异。结论：盐酸洛美沙星盐水注射液与其葡萄糖液类似。
Objective: To study the acute toxicity of lomefloxacin hydrochloride. Methods: According to the pharmacological experimental method, the LD50 and 100 Kunming mice were randomly divided into 5 groups and injected intravenously. The number of death in each group was observed within 48 hours. Results: Lomefloxacin hydrochloride female mice group, LD50 = 255.3mg / kg; male mice LD50 = 251.2mg / kg, compared with lomefloxacin hydrochloride glucose injection (LD50 = 261.2mg / kg) Significant differences. Conclusion: Lomefloxacin hydrochloride saline injection is similar to glucose solution.