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目的:研究卵巢过度刺激综合征(OHSS)高危患者取卵后使用来曲唑对黄体期性激素的影响及对OHSS的预防作用。方法:193例患者196个OHSS高危体外受精(IVF)/卵胞浆单精子注射(ICSl)周期取卵后行全部胚胎冷冻,并于取卵后根据是否添加来曲唑分为实验组和对照组,实验组取卵后口服来曲唑,对照组不予来曲唑。比较两组患者HCG日(d0)、d2、d4、d9的LH、E2、P水平及中、重度OHSS发生率。结果:实验组和对照组d0和d2的LH、E2、P以及d4LH和P、d9LH和P差异均无统计学意义(P>0.05),实验组d4 E2、d9E2和中、重度OHSS率低于对照组(P<0.01)。结论:OHSS高危患者取卵后添加来曲唑显著降低黄体期E2水平,有效降低中、重度OHSS发生率。
OBJECTIVE: To study the effect of letrozole on luteal phase sex hormones after ovulation and its preventive effect on OHSS in high-risk patients with ovarian hyperstimulation syndrome (OHSS). METHODS: A total of 196 embryos were frozen from 196 OHSS IVF / ICSl cycles in 193 patients and divided into experimental group and control group according to whether letrozole was added after ovulation Group, the experimental group orally taking letrozole, the control group not to letrozole. The levels of LH, E2, P and the incidence of moderate and severe OHSS on HCG day (d0), d2, d4 and d9 in both groups were compared. Results: There was no significant difference in LH, E2, P, d4LH, P, d9LH and P between d0 and d2 in experimental group and control group (P> 0.05). The rates of d4 E2, d9E2 and moderate and severe OHSS in experimental group and control group were lower than Control group (P <0.01). Conclusion: Letrozole oocyte retrieval after oocyte retrieval in high-risk OHSS patients can significantly reduce the E2 level in the luteal phase and effectively reduce the incidence of moderate and severe OHSS.