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目的通过横断面研究,了解主动脉瓣硬化在一组高危人群中发病情况,并评价主动脉瓣硬化的临床危险因素。方法 1058例首钢社区动脉硬化调查的队列人群,排除了风湿性瓣膜病、主动脉瓣二叶瓣畸形、人工瓣膜置换术后、主动脉瓣狭窄。测定并评价心血管疾病的危险因素(包括年龄、血压、血糖、血脂、体质指数和吸烟情况)。根据经胸心脏超声评价主动脉瓣硬化病变情况,并将人群分为主动脉瓣硬化组和主动脉瓣正常组。结果最终入选1039例人群,平均年龄62.47±8.99岁,明确患有高血压病占68.72%,糖尿病占25.89%。发生主动脉瓣硬化401例(38.59%)。年龄每增加10岁是原来发生瓣膜硬化危险的1.589倍(P<0.001);男性发生瓣膜硬化的危险是女性的2.263倍(P<0.001);患高血压病人群发生瓣膜硬化的危险是无高血压的1.296倍(P=0.063),而患糖尿病的人发生瓣膜硬化的危险是无糖尿病的1.794倍(P<0.001)。经多因素Logistic回归分析,发现主动脉瓣硬化独立危险因素包括年龄增加(OR=1.507,P<0.001)、男性(OR=1.974,P=0.003)、高血压(OR=1.428,P=0.015)和糖尿病(OR=1.719,P<0.001)。结论主动脉瓣硬化的发生是多个因素共同参与的复杂病理过程。主动脉瓣硬化与动脉硬化有着许多共同的危险因素,提示这些危险因素可能通过类似的机制参与了瓣膜硬化发生、发展过程。
Objective To understand the incidence of aortic valve flaccid in a group of high-risk population by cross-sectional study and evaluate the clinical risk factors of aortic valve sclerosis. Methods A cohort of 1058 cases of atherosclerosis in Shougang community were excluded from rheumatic valvular disease, aortic valve deformity, aortic valve stenosis and aortic valve stenosis. The risk factors for cardiovascular disease (including age, blood pressure, blood sugar, lipids, body mass index and smoking) were determined and evaluated. According to transthoracic echocardiography aortic valve sclerosis lesions, and the population is divided into aortic valve sclerosis group and aortic valve normal group. Results The final population of 1039 patients was selected, with an average age of 62.47 ± 8.99 years, with a clear prevalence of hypertension of 68.72% and diabetes of 25.89%. Aortic valve flaps occurred in 401 cases (38.59%). For each 10-year increase in age, there was 1.589-fold greater risk of valvular hardening (P <0.001); for men, 2.263-fold greater risk of valvular stiffness was found in women than in women (P <0.001); in patients with hypertension, Blood pressure was 1.296 times (P = 0.063), while those with diabetes were 1.794 times more likely to develop valvular stiffness than those without diabetes (P <0.001). The multivariate Logistic regression analysis showed that the independent risk factors of aortic valve disease included age (OR = 1.507, P <0.001), male (OR = 1.974, P = 0.003), hypertension (OR = 1.428, P = 0.015) And diabetes (OR = 1.719, P <0.001). Conclusion The occurrence of aortic valve sclerosis is a complicated pathological process involving many factors. Aortic valve sclerosis and atherosclerosis have many common risk factors, suggesting that these risk factors may be involved in a similar mechanism of valve sclerosis occurrence and development process.