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本文报道15例甲型肝炎病人从发病后2周到1年期间抗 HAV-IgM 和抗 HAV-IgG 的动态变化.实验结果表明抗 HAV-IgM 的滴度,高峰时为10~(-5)～10~(-7)。儿童在发病后3个月左右抗 HAV-IgM 全部转阴。部分成人则转阴时间相对长些。抗 HAV-IgG 高峰时最高滴度有10~(-8),一般为10~(-5)～10~(-7),有的病人在发病后3个月左右出现高峰,以后逐渐下降,也有出现高峰后持续不下降者。有的病人发病后2周即出现10~(-7),一年中持续高滴度,也有半年左右即降至临界值者.这反映了不同病人对 HAV 应答的多样性。本实验采用 ELISA 法,所用组织培养物经高度纯化后得到的 HAAg,增加了实验的敏感性和可靠性。
This article reports the dynamic changes of anti-HAV-IgM and anti-HAV-IgG in 15 patients with hepatitis A from 2 weeks to 1 year after onset.The results showed that the titer of anti-HAV-IgM was 10 ~ (-5) ~ 10 ~ (-7). Anti-HAV-IgM was all negative in children about 3 months after onset. Some adults turn negative longer time. The highest titer of anti-HAV-IgG peak was 10 ~ (-8), usually 10 ~ (-5) ~ 10 ~ (-7). Some patients peaked at about 3 months after onset and then decreased gradually. There are also continued to decline after the peak appeared. Some patients appear 10 weeks after 2 weeks of onset, high titers in a year, there are about half a year that fell to the critical value.This reflects the diversity of response to HAV in different patients. The experiment using ELISA method, the highly purified tissue culture obtained HAAg, increased the sensitivity and reliability of the experiment.