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:目的 :提供人类神经系统中乙脑病毒持续感染的免疫学和病毒学依据。方法 :经临床诊断为乙脑的 2 4 9例患者中 ,经血清和 C.S.F免疫学确诊者 2 18例 ,采用抗 μ链抗体捕获法、反向被动血凝法和小鼠脑内接种法 ,分别对患者 C.S.F中特异性 Ig M、乙脑病毒抗原及乙脑病毒作定期追踪检测。结果 :12 / 2 18( 5.5% )经 C.S.F特异性 Ig M、乙脑病毒抗原和病毒分离 ,符合乙脑病毒持续感染标准。结论 :对传统的乙脑后遗症概念的内涵提出了新的视点。
: Purpose: To provide immunological and virological evidence for the sustained infection of Japanese encephalitis virus in the human nervous system. Methods: Among 299 patients who were diagnosed as JE by clinical diagnosis, 21 cases were diagnosed by serum and CSF immunology. Anti-μ-chain antibody capture, reverse passive hemagglutination and intracerebral inoculation were used. Specific CSF IgM, JE virus antigen and JE virus were regularly followed up. Results: 12/2 18 (5.5%) were separated by C.S. F specific IgM, JE virus antigen and virus, meeting the standard of persistent infection of JE virus. Conclusion: This article proposed a new perspective on the connotation of the traditional concept of JE sequelae.